pysam
Pysam - Genomic Alignments
Used for high-throughput sequencing pipelines. It allows efficient access to billions of DNA fragments aligned to a reference genome.
When to Use
- Processing next-generation sequencing (NGS) data.
- Analyzing genomic variants (SNPs, indels).
- Extracting reads from specific genomic regions.
- Building custom bioinformatics pipelines.
- Quality control of sequencing data.
Core Principles
Indexed Access
BAM files must be indexed (.bai) for efficient random access to genomic regions.
Coordinate System
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