AlphaFold Protein Structure Database API

Overview

The AlphaFold DB, maintained by EMBL-EBI and DeepMind, provides open access to over 200 million protein structure predictions. The REST API enables programmatic lookup of predicted structures, confidence metrics (pLDDT, PAE), and downloadable structure files (PDB, mmCIF, BinaryCIF) keyed on UniProt accessions. Free, no authentication required.

Authentication

None. All endpoints are publicly accessible without API keys or tokens.

Core Endpoints

Base URL: https://alphafold.ebi.ac.uk/api

1. Get Prediction by UniProt Accession

Retrieves all AlphaFold models for a given UniProt accession or model ID.