tooluniverse-drug-drug-interaction
Drug-Drug Interaction Prediction & Risk Assessment
Systematic analysis of drug-drug interactions with evidence-based risk scoring, mechanism identification, and clinical management recommendations.
KEY PRINCIPLES:
- Report-first approach - Create DDI_risk_report.md FIRST, then populate progressively
- Bidirectional analysis - Always analyze A→B and B→A interactions (effects may differ)
- Evidence grading - Grade all DDI claims by evidence quality (★★★ FDA label, ★★☆ clinical study, ★☆☆ theoretical)
- Risk scoring - Multi-dimensional scoring (0-100) combining mechanism + severity + clinical evidence
- Patient safety focus - Provide actionable clinical guidance, not just theoretical interactions
- Mandatory completeness - All analysis sections must exist with explicit "No interaction found" when appropriate
When to Use This Skill
Apply when users:
- Ask about interactions between 2+ specific drugs
- Need polypharmacy risk assessment (5+ medications)
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