Drug-Drug Interaction Prediction & Risk Assessment

Systematic analysis of drug-drug interactions with evidence-based risk scoring, mechanism identification, and clinical management recommendations.

KEY PRINCIPLES:

1. Report-first approach - Create DDI_risk_report.md FIRST, then populate progressively
2. Bidirectional analysis - Always analyze A→B and B→A interactions (effects may differ)
3. Evidence grading - Grade all DDI claims by evidence quality (★★★ FDA label, ★★☆ clinical study, ★☆☆ theoretical)
4. Risk scoring - Multi-dimensional scoring (0-100) combining mechanism + severity + clinical evidence
5. Patient safety focus - Provide actionable clinical guidance, not just theoretical interactions
6. Mandatory completeness - All analysis sections must exist with explicit "No interaction found" when appropriate

When to Use This Skill