Drug Target Validation Pipeline

Validate drug target hypotheses using multi-dimensional computational evidence before committing to wet-lab work. Produces a quantitative Target Validation Score (0-100) with priority tier classification and GO/NO-GO recommendation.

KEY PRINCIPLES:

1. Report-first approach - Create report file FIRST, then populate progressively
2. Target disambiguation FIRST - Resolve all identifiers before analysis
3. Evidence grading - Grade all evidence as T1 (experimental) to T4 (computational)
4. Disease-specific - Tailor analysis to disease context when provided
5. Modality-aware - Consider small molecule vs biologics tractability
6. Safety-first - Prominently flag safety concerns early
7. Quantitative scoring - Every dimension scored numerically (0-100 composite)
8. Negative results documented - "No data" is data; empty sections are failures
9. Source references - Every statement must cite tool/database
10. Completeness checklist - Mandatory section showing analysis coverage
11. English-first queries - Always use English terms in tool calls. Respond in user's language