GWAS Trait-to-Gene Discovery

Discover genes associated with diseases and traits using genome-wide association studies (GWAS)

Overview

This skill enables systematic discovery of genes linked to diseases/traits by analyzing GWAS data from two major resources:

• GWAS Catalog (EBI/NHGRI): Curated catalog of published GWAS with >500,000 associations
• Open Targets Genetics: Fine-mapped GWAS signals with locus-to-gene (L2G) predictions

Use Cases

Clinical Research

• "What genes are associated with type 2 diabetes?"
• "Find genetic risk factors for coronary artery disease"
• "Which genes contribute to Alzheimer's disease susceptibility?"