tooluniverse-gwas-trait-to-gene
GWAS Trait-to-Gene Discovery
Discover genes associated with diseases and traits using genome-wide association studies (GWAS)
Overview
This skill enables systematic discovery of genes linked to diseases/traits by analyzing GWAS data from two major resources:
- GWAS Catalog (EBI/NHGRI): Curated catalog of published GWAS with >500,000 associations
- Open Targets Genetics: Fine-mapped GWAS signals with locus-to-gene (L2G) predictions
Use Cases
Clinical Research
- "What genes are associated with type 2 diabetes?"
- "Find genetic risk factors for coronary artery disease"
- "Which genes contribute to Alzheimer's disease susceptibility?"
Drug Target Discovery
- Identify genes with strong genetic evidence for disease causation
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