Polygenic Risk Score (PRS) Builder

Build and interpret polygenic risk scores for complex diseases using genome-wide association study (GWAS) data.

Overview

Use Cases:

• "Calculate my genetic risk for type 2 diabetes"
• "Build a polygenic risk score for coronary artery disease"
• "What's my genetic predisposition to Alzheimer's disease?"
• "Interpret my PRS percentile for breast cancer risk"

What This Skill Does:

• Extracts genome-wide significant variants (p < 5e-8) from GWAS Catalog
• Builds weighted PRS models using effect sizes (beta coefficients)
• Calculates individual risk scores from genotype data
• Interprets PRS as population percentiles and risk categories