tooluniverse-polygenic-risk-score
Polygenic Risk Score (PRS) Builder
Build and interpret polygenic risk scores for complex diseases using genome-wide association study (GWAS) data.
Overview
Use Cases:
- "Calculate my genetic risk for type 2 diabetes"
- "Build a polygenic risk score for coronary artery disease"
- "What's my genetic predisposition to Alzheimer's disease?"
- "Interpret my PRS percentile for breast cancer risk"
What This Skill Does:
- Extracts genome-wide significant variants (p < 5e-8) from GWAS Catalog
- Builds weighted PRS models using effect sizes (beta coefficients)
- Calculates individual risk scores from genotype data
- Interprets PRS as population percentiles and risk categories
What This Skill Does NOT Do:
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