RCT Comprehensive Appraisal

Overview

This skill enables systematic, reproducible appraisal of randomized controlled trial (RCT) papers through:

1. Multi-framework integration - CONSORT 2025, Cochrane RoB 2.0, GRADE, TIDieR, Benefits/Harms, COI assessment
2. Comprehensive bias assessment - Systematic evaluation across 5 risk of bias domains with ~30 signaling questions
3. Benefits and harms evaluation - Structured assessment of therapeutic benefits, adverse events, and risk-benefit balance
4. Conflicts of interest analysis - Systematic COI detection and impact evaluation
5. Evidence certainty grading - GRADE framework for rating confidence in effect estimates
6. Dual-validation methodology - Independent concurrent appraisals with concordance analysis
7. Editorial writing support - Generate evidence-based 1500-word editorial content on RCT quality

The skill transforms RCT critical appraisal from a subjective, variable process into a systematic, evidence-based workflow (~2-4 hours depending on scope).

When to Use This Skill