COBRApy - Constraint-Based Reconstruction and Analysis

Overview

COBRApy is a Python library for constraint-based reconstruction and analysis (COBRA) of metabolic models, essential for systems biology research. Work with genome-scale metabolic models, perform computational simulations of cellular metabolism, conduct metabolic engineering analyses, and predict phenotypic behaviors.

When to Use This Skill

Use this skill when the user wants to:

• Load a genome-scale metabolic model (SBML/JSON/YAML) and simulate growth with FBA/pFBA.
• Predict knockout phenotypes, essential genes, or minimal media.
• Explore flux space with FVA, flux sampling, or production envelopes.
• Build, gapfill, or curate a constraint-based model.

Does NOT Trigger