bio-differential-splicing

Installation
SKILL.md

Version Compatibility

Reference examples tested with: rMATS-turbo 4.3+, SUPPA2 2.4+, leafcutter 0.2.9+, MAJIQ 3.0+, Shiba 0.5+, STAR 2.7.11+, regtools 1.0+, pandas 2.2+, R 4.4+

Before using code patterns, verify installed versions match. If versions differ:

  • Python: pip show <package> then help(module.function) to check signatures
  • R: packageVersion('<pkg>') then ?function_name to verify parameters
  • CLI: <tool> --version then <tool> --help to confirm flags

If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.

Differential Splicing

Detect splicing changes between conditions. Tool choice is a decision about statistical model, annotation dependence, and calibration regime under the specific experimental design — not a preference. Wrong tool for the design produces uncalibrated FDR or systematic effect-size bias.

Statistical Model Taxonomy

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