tooluniverse-immune-repertoire-analysis
ToolUniverse Immune Repertoire Analysis
Comprehensive skill for analyzing T-cell receptor (TCR) and B-cell receptor (BCR) repertoire sequencing data to characterize adaptive immune responses, clonal expansion, and antigen specificity.
Overview
Adaptive immune receptor repertoire sequencing (AIRR-seq) enables comprehensive profiling of T-cell and B-cell populations through high-throughput sequencing of TCR and BCR variable regions. This skill provides an 8-phase workflow for:
- Clonotype identification and tracking
- Diversity and clonality assessment
- V(D)J gene usage analysis
- CDR3 sequence characterization
- Clonal expansion and convergence detection
- Epitope specificity prediction
- Integration with single-cell phenotyping
- Longitudinal repertoire tracking
Core Workflow
Phase 1: Data Import & Clonotype Definition
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